Comfort In Parenteral Delivery

Automated device functions and safety features make parenteral administration less onerous for self-treating patients.

Advanced parenteral delivery solutions are affording product differentiation and therapeutic benefits across a range of therapies.

In needle-based injection, cartridge-based pens and prefilled syringes loaded into disposable auto injector devices offer features that support easier self administration by patients.

Antares Pharma Vibex injectors feature adjustable needle penetration and adjust to alter injection speed for viscous product.

Used for daily therapies and those less frequently administered, these devices require fewer steps and make the injection process less difficult and safer. As more easily used delivery systems, they promote regimen adherence among self-treating patients.

In transdermal delivery through patch and gel technologies, the side effects of orally administered drugs that often cause noncompliance are reduced or avoided.

Needle-free injection therapy systems—promising for applications including pediatric vaccines and self-administered injections for chronic conditions—also address patient adherence, as patients facing daily injection don’t also have to face a needle.

Genentech (www.gene.com) provides unique features that support patient dosing with the Nutropin AQ NuSpin, a prefilled multi-dose injection pen, for administration of Nutropin [somatropin (rDNA origin) injection], a recombinant growth hormone.
After the launch of Nutropin AQ NuSpin in 2009 for the adult human growth hormone market, Genentech announced availability of the system in 2010 for the pediatric market.

Advanced features of the device improve patient ease-of-use compared to Genentech’s earlier AQ Nutropin pen, a reusable device that requires patients to load in the cartridges. Delivered prefilled with the cartridge, the Nutropin NuSpin is disposed of after use. The device comes prefilled with 5-, 10-, and 20-mg cartridges, denoted by different device colors.

VISUAL CUES

The patient sets the dose using a unique “spinning” dose knob that spins as the dose is administered. The selected dose amount is shown in a small window, says Donna French, senior director, device development, Genentech.

“The spinning knob provides a strong visual indicator. The patient can be assured when the injection starts, when it is happening, and when it is finished. (In addition), if the patient accidentally over turns the knob in setting the dose, it can be turned back and forward with ease to select the correct dose,” French says.

After the needle is inserted into the skin, the drug is automatically delivered after the patient moves a sliding dose activator on the side of the pen.

“The drug is pushed through the needle into the subcutaneous space automatically. With Nutropin NuSpin, we have the only
disposable pen on the market with automated drug delivery. Patient feedback has been excellent,” French says.

Genentech has partnered with two contract manufacturing organization (CMOs) to produce a market ready product, says Gerald Llorach, head of combination products, CMOs.

One makes the device; the second fills the cartridges and performs final assembly for delivery to a Genentech distribution center.
Antares Pharma (www.antarespharma.com) offers technology platforms for self-injection of drug products as well as for transdermal delivery. Automatic injecting devices such as Antares’s Vibex pressure-assisted auto injector platform leverage technology first developed for the company’s Medi-Jector needle-free delivery system.

Concepts employed in the Medi-Jector are applied to Antares’s mini-needle auto injectors for rapid and confortable self-injection.
“We have one of the most powerful spring-generated injection technologies available. We have applied the Medi-Jector technology to auto injectors for subcutaneous and intramuscular delivery in devices that have to withstand the pressures generated during injection with this technology,” says Paul Wotton, PhD, Antares president and CEO.

PAIN Avoidance

“As a company with a lot of history with this type of injection technology, our mission is to make it easier for patients to self-inject at home without fear of pain,” Wotton says.

In addition to out-licensing its technology platforms, Antares is developing its own pharmaceutical products and partners with pharmaceutical companies to develop and commercialize novel parenteral drug/device combination products using its drug delivery systems.

“There is a huge need for systems that help companies differentiate product in the market while promoting patient safety, enhanced comfort, and adherence. Of the $50 billion U.S. market for biological products, we estimate that self-administered products account for over half the total,” Wotton says.

“(Also) biological drugs tend to present injection challenges due to the viscosity of the solutions. Injection devices designed to improve patient comfort and compliance will be crucial to differentiating biological products, particularly biosimilar versions of marketed biologics,” he adds.

In needle-free delivery using Antares’s Vision technology, the device releases a thin stream of the drug that permeates through the outer layer of the skin into the tissue undernealth. The system is used in Teva Pharmaceuticals’ Tjet device for injection of Tev-Tropin human growth hormone (hgh). In Europe, Ferring Pharmaceuticals provides Zomacton hgh in
Antares Zomajet 2 Vision and Zomajet Vision X devices.

Last month Antares announced the dosing of the first patient in a clinical study evaluating Vibex MTX, being developed for the treatment of rheumatoid arthritis. Vibex MTX is Antares’s proprietary methotrexate injection system for patient self administration of the drug. The subcutaneous delivery system offers an alternative to conventional needle and syringe administration by a caregiver, and to oral dosing.

“Many patients are not able to tolerate methotrexate when given orally. Also, injection delivery minimizes dosing variability. The dosing is not easily reproducible when taken orally especially at higher doses,” Wotton says.

“Methotrexate for injection is increasing used in this country for rheumatoid arthritis patients. Our research has shown that given a practical means of enabling subcutaneous administration, rheumatologists would offer the option to many patients who either don’t tolerate or adequately absorb methotrexate,” he adds.

Delivered to the patient as a ready to use unit, Vibex MTX incorporates the drug in a prefilled syringe and needle. Antares’s partner Uman Pharma (Montreal) formulates and packages the drug into syringes for final assembly into the device.

RAPID INJECTION

In use, the patient flips off a safety cover, removes the needle cap, and pushes the device against the skin. When pushed against the skin, a collar retracts to expose the needle to a shallow depth, triggering delivery.
“It’s a comfortable procedure. The collar pressure distracts the patient a bit so you don’t feel the needle. We are trying to make injection as easy for the patient as taking a pill, while also improving therapeutic performance,” Wotton says.

Wotton notes that auto injection with typical injectors takes seven to ten seconds. “The whole procedure using Vibex takes three seconds and the injection of a ½-ml or 1-ml dose is accomplished in a second or less,” he says.

Vibex’s coil-spring system is also paired with the allergy emergency drug epinephrine in a disposable, single use injection developed with Teva Pharma as a generic version of the EpiPen.

In transdermal drug delivery, Antares is developing Anturol for treatment of over active bladder. Based on the company’s Advanced Transdermal Delivery (ADT) Gel technology, Anturol is formulated as a version of oxybutynin for optimizing the drug delivery in a non-patch transdermal form. Antares filed an NDA for Anturol in December 2010.

“It has been well recognized that transdermal delivery of drugs is a safe and effective way of delivering certain drugs that undergo first pass gastric and hepatic metabolism. We’re hoping for approval in the next 12 months,” Wotton says.

The ADT Gel technology is also used to deliver Azur Pharma’s FDA-approved Elestrin menopause drug, in NestraGel, a Phase II contraceptive being developed with the Population Council, and in BioSante Pharma’s Phase III female sexual dysfunction drug LibiGel.

 

Your rating: None Average: 5 (3 votes)

THESE ARE ALL INFORMATIVE SOURCES

Best

Meanwhile, here are some quick tips to make your travel easier. This travel tips help you schedule your time and money. Hi this is Michael Micheli and I'm planning a trip on my bike too, backlink directory living San Francisco California to Argentina, and mi to traveling on a low buget camping I'm Original from Argentina so Ablo Espanol, I'm flexibol on time, I love to take my time thinking to cross New Ladero lest keep in touch.

Hello

Those people also need programmers to divide tasks and estimate time.For sure many student don't want that ROTC to be included on their university, and if they imposed it mandatory, website optimization I guess follow some personal rights which protects the dignity of every student by having that Don't ask Don't tell policy.The cost of education is really becoming very expensive for average students and I think something should be done about it baseball field covers.

well-written

Sant Ritz is also near elite schools such as St. Andrew’s Secondary School and St. Andrew’s Junior College. Cedar Girls’ Secondary School and CedarPrimary School are also around in the area. For vehicle owners, it takes less than 10 minutes to drive to the business hub and vibrant Orchard Road shopping district, via Pan Island Expressway (PIE) and Central Expressway (AYE).

Hi

chip runner kostenlos spielen easy with your presentation but I find this topic to be really something which I think I would never understand. sizzling hot kostenlos spielen

A delivery process that can

A delivery process that can be done easily it could be one of the things that makes a lot of people can be confident with it. You can find lots of ways to be able to perfect the process.
LinkHelpers

I was looking for something

I was looking for something completely different, but found your webpage! And have to say thanks. Nice read.
Visa Iran

All matters relating to the

All matters relating to the delivery process can indeed be one of the difficult things done by people who still lay. You must have experience first. Progressive Rock

great

Let me try this out with business and how to get it on water softener salt free

Wonderful being going to your

Wonderful being going to your blog once again, it's been weeks to me. This report in which i am silently laid for such a long ti me. I would like this information to complete my own project within the school, and possesses exact same topic using your. click aquí

Well researched one. I got so

Well researched one. I got so much real stuff from your blog. I hope that more people read this and get what I got from it: chills. Great job and great blog. I cant wait to read more, keep em coming! electrosmog

Not all people can easily

Not all people can easily think well throughout those circumstance. Consequently, it really is necessary a number of visitors to aid. click aquí

If they feel comfort, then

If they feel comfort, then keep using it. So there will be nothing bad happen.
Cold Laser Dallas

I am impressed

Tanah Merah New Launch is also near to Laguna Tennis & Nation Group and Safra Tennis & Nation Group. Entertainment for your near near close relatives is therefore at your satisfaction with the complete property functions as well as the alternatives near Urban Vista.
Thx

Thanks for sharing this.

Thanks for sharing this. We're always looking for smart resources to share with clients and my colleagues, and this article is certainly worth sharing! click aquí

nice blog

This article gives the light in which we can observe the reality. Interesting post and thanks for sharing. Some things in here I have not thought about before.Thanks for making such a cool post which is really very well written.will be referring a lot of friends about this.Keep blogging.I am glad to found such useful post. I really increased my knowledge after read your post which will be beneficial for me. Malibu Garage Door Repair

You actually make it appear

You actually make it appear so easy with your performance but I find this affair to be actually something which I think I would never comprehend. It seems too complex and extremely broad for me. I'm looking forward for your next post, I’ll try to get the hang of it! Allevamento Rottweiler

Really nice

You actually make it look so easy with your performance but I find this matter to be actually something which I think I would never comprehend. It seems too complicated and extremely broad for me. Sunmaker| Joker Cap I'm looking forward for your next post, I’ll try to get the hang of it!I agree with your Blog and I will be back to inspect it more in the future so please keep up your act. A good blog always comes-up with new and exciting information and while reading I have feel that this blog is really have all those quality that qualify a blog to be a one.I wanted to leave a little comment to support you and wish you a good continuation. Wishing you the best of luck for all your blogging efforts.

Valuable post!

I am visited many other blog site and read attentively your each post. Afrer reading your post i could understand that the content is most simple and great. Thank you for your great share. Also this is my 1st visit at your site and after visiting your site i enjoyed.
http://www.southcaforeclosureprevention.com/

Message

Karnevalskostueme Nicely presented information in this post, I prefer to read this kind of stuff. The quality of content is fine and the conclusion is advantage.

casino

I like this concept a balanced analysis. Looking at the comments posted, it is hard to believe that someone who advocated for a larger stimulus in this interview could be accused of having conservative leanings Joker Cap Quite an odd, or more likely, willfully blind to the electoral maths, conclusion.The site owner has carried out a superb job of putting it together, the info here is really insightful.Triple Chance spielenNow i am going to bookmark this internet site so that I can revisit in the future Jobs.

where to sell my watch for

where to sell my watch for the most money You actually make it appear so easy with your performance but I find this affair to be actually something which I think I would never comprehend. It seems too complex and extremely broad for me.

Rahul

Thanks for this good article. Good Share. Thanks for the amazing content on your blog I am very interested in this article and you have really helped me. packages manali and for more info. visit this page.

cuadros electricos

There are a lot of great points here, but I'm not sure I agree with real-time search being discarded. I agree that it's not very relevant,but isn't the point of it to show what people are currently saying about a topic.
cuadros electricos

There are times when we do

There are times when we do have to look for new devices associated with treatment to be able to know and understand that there will be many developments in this field.
Bellevue Mover

Ou ka jwenn lyen ki mennen

Ou ka jwenn lyen ki mennen nan finanse kado nan retounen pou piblisite. Yon lòt bonis avèk ou kenbe konpetisyon epi kite non ou, nimewo telefòn ak adrès postal yo se ou gen yon lis non ki kapab itilize nan kanpay la.
dermatologist houston

great blog

Players there are a large selection of casinos available and they can freely wählen.Wer wants to play casino games for free without registration, the need to be aware that he must then choose between real money and play money! Who wants to play with real money, which can not avoid a booking.Fruitinator Download When registering a player account is created, which can then in the desired amounts are paid. For this purpose,Blazing Star kostenlos many casinos now offer already a decent welcome bonus. Not infrequently, the casinos doubled while the player's first deposit. However, if you wish casino spiele kostenlos ohne anmeldung

Seattle Skin Care This is

Seattle Skin Care This is best site to spent time on .I just stumbled upon your chatty blog and wanted to say that I have really enjoyed reading your very well written blog posts. I will be your frequent visitor, that's for sure.

You can indeed find a lot of

You can indeed find a lot of tools that can help you do a lot of things related to medical. This indeed may be one thing that is very helpful indeed. sound machine

You can indeed find a lot of

You can indeed find a lot of modern and sophisticated devices that can eliminate racial hurt when you use it. This can indeed be one movie trailers

It is really a nice and

It is really a nice and helpful piece of info. I'm glad that you shared this helpful information with us and Very happy to see your article, I am very much to like and agree with your point slot machine kostenlos of view.And what better than this small version, which is the epitome of evening-wear chic.There are Strapless equipped, small dew fragrant shoulder is feminine.Your blog is so interesting and very informative.Thanks sharing. Definitely a great piece of work Thanks for your work

Amazing post!

This is really a fascinating blog, lots of stuff that I can get into. One thing I just want to say is that your design is so perfect! Afrer reading your post i could understand that the content is most simple and great. Thank you for your great share. Also this is my 1st visit at your site and after visiting your site i enjoyed.
oktoberfest tours

Fresh anecdote

New super hero - Man - student.
He manages to make as many feats for December
how much should be done in September, October and November!

nice info

Thanks for sharing this opinion. Regards for you. Good job! Very helpful information This is a cool blogging platform.buy instagram followers

Amazing post!

I am visited many other blog site and read attentively your each post. Afrer reading your post i could understand that the content is most simple and great. Thank you for your great share. Also this is my 1st visit at your site and after visiting your site i enjoyed.
sell my house in moreno valley

ased

Extra 10 Liner
Super 7 Reels kostenlos spielen
The good news is our friends at RueLaLa constantly update their site with some of the best bags available.

Informative

I have found your articles through competitors sites link. Really you have a fantastic, useful product related to health.
los angeles massage

goodside

Merkur Spielautomaten online || Merkur Magnus online A good blog always comes-up with new and exciting information and while reading I have experience that this blog is really have all those quality that characterize a blog to be a good one.

Its a great article help the

Its a great article help the people to reduce their cost. Tempur-pedic

goodside

Triple Chance Tricks || Triple Chance online kostenlos A good blog always comes-up with new and exciting information and while reading I have experience that this blog is really have all those quality that characterize a blog to be a good one.

prevent

North Face Jackets Sale Do you have any solutions to prevent hackers?North Face Denali Hoodie

heeeey

Private Krankenversicherung There are a lot of blogs and articles out there on this topic, but you have acquired another side of the subject. This is reliable content thank you for sharing it.

Autocom CDP Pro

The Ferrari 599 Hybrid Concept
Volvo Dice Vidaweights 100 kg more than the standard 599 but with this added 100 HP from the electric motor, the hybrid model is actually faster than the stock version of the 599. Ferrari is Autocom CDP Pro planning to turn this concept into a production model in a few years but we will probably get more details about this
OBD2 Scan Tool, lexia 3 v47 hybrid next week.nside, the Encore has either cloth or leather-appointed seats, depending on the trim. The dash board is sculpted with soft-touch materials and wood trim that deliver a sense luxury. The gauge cluster and center console are laid out well, easy to use and within reach. Want storage? The Encore has
Cable for Renault Can Clip plenty with two glove boxes, lots of in-door space and a space in the center console.DEMI

business valuation Really

business valuation Really impressed! Everything is very open and very clear reason of issues. It contains truly news. Your website is very valuable. Thanks for sharing.

american airlines A reliable

american airlines A reliable informative post that you have shared and appreciate your work for sharing the information. Got some entertaining information and would like to provide it a try. Applaud your work and keep sharing your information.

Organitzacions benèfiques i

Organitzacions benèfiques i clubs esportius estan sempre a la recerca de negocis com regals dels donants en forma de patrocini. Les empreses que donen béns o serveis s'ofereixen generalment en forma de punt de mira la publicitat com el logotip en els materials promocionals.
girls formal dresses

See vorm turundus kui üha

See vorm turundus kui üha populaarsemaks, eriti viimase kahe või kolme aasta konkursi üha tiheneva väljas stendid. Ütlematagi selge, et näidatava objekti kohta katuse äri kus saab tähelepanu.
cna school online

That is very interesting

That is very interesting Smile I love reading and I am always searching for informative information like this. This is exactly what I was looking for.
clubmz e-spy
clubmz reviews

This is my first time i visit

This is my first time i visit here. I found so many interesting stuff in your blog especially its discussion. From the tons of comments on your articles, I guess I am not the only one having all the enjoyment here keep up the good work..
free mobile phone spying

plastic surgeon dallas I

plastic surgeon dallas I have explain so many article of this site in which some of them were very intresting and inspiring.This article has good title with good description.